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The physician should periodically reassess the usefulness of the drug for the individual patient.Ĭoncomitant use of benzodiazepines, including Valium, and opioids may result in profound sedation, respiratory depression, coma, and death. The effectiveness of Valium in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. Oral Valium may be used adjunctively in convulsive disorders, although it has not proved useful as the sole therapy. Valium is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma), spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia), athetosis, and stiff-man syndrome. In acute alcohol withdrawal, Valium may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Valium is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue VALIUM or reduce the dosage (see DOSAGE AND ADMINISTRATION and WARNINGS). Abrupt discontinuation or rapid dosage reduction of VALIUM after continued use may precipitate acute withdrawal reactions, which can be life-threatening. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose.

The continued use of benzodiazepines, including VALIUM, may lead to clinically significant physical dependence.

Before prescribing VALIUM and throughout treatment, assess each patient's risk for abuse, misuse, and addiction (see WARNINGS). Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes.

The use of benzodiazepines, including VALIUM, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.

Follow patients for signs and symptoms of respiratory depression and sedation (see WARNINGS and PRECAUTIONS). Limit dosages and durations to the minimum required.

Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.

Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS ABUSE, MISUSE, AND ADDICTION and DEPENDENCE AND WITHDRAWAL REACTIONS